Sensitivity Pattern of Some Antifungal Drugs on Fungi Isolated from Soil

Abstract

Presently, no agar-based susceptibility testing method has been perpetuated for testing moulds. We describe a newly developed agar-based method using agar well diffusion method to examine the susceptibility of 6 moulds against 2 antifungals. Our findings show that the method is reproduceable. Fungi isolated from different soil samples for a period of eight weeks within the University of Ilorin, were analysed for their sensitivity to different concentrations of two antifungal tablets (Ketoconazole and Griseofulvin). The antifungal activities were evaluated using agar well diffusion method. The assay was carried out on the isolated and identified fungi: Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus, Mucor racemosus, Rhizopus stolonifer, and Fusarium oxysporium. The results showed that the fungal isolates were susceptible to griseofulvin and ketoconazole. This study showed that ketoconazole has greater inhibitory potential and broad spectrum of activity than griseofulvin.