Synthesis, Characterization and Antimicrobial Activity Study of metal (II) Complexes of Mixed Acetylsalicylic acid and 1, 10- phenanthroline

Abstract

A  series of  Mn(II), Fe(II), Co(II), Cu(II) and Zn(II) mixed ligands-metal complexes derived from 1,10-phenanthroline (PHEN) and acetylsalicylic acid (ASP) have been synthesized. The compounds were characterized using elemental analysis, infrared, ultraviolet/visible spectroscopies and X-ray powder diffraction .The coordination of the two ligands towards the central metal ion has been proposed in the light of elemental analysis, infrared, ultraviolet/ visible, and X-ray powder diffraction spectroscopic studies. The results of the physical and spectroscopic data confirmed that the ligands are bidentate chelating agents. In 1, 10-phenanthroline, coordination occurred through the two pyridinic nitrogen groups. Acetylsalicylic acid complexes coordinate through the carbonyl oxygen of the carboxyl and the ester groups. The compounds form a six- coordinate geometry. Antimicrobial activity of the mixed ligand metal complexes and the free ligands were carried out against the bacteria: Escherichia coli, staphylococcus aureus, klebsiella pneumonia, pseudomonas aeruginosa and the fungi candida spp. The mixed ligands metal complexes showed higher activities when compared to the free ligands of acetylsalicylic acid but were less active than the free 1, 10-phenanthroline ligand. The complexes of Mn (II) showed significant antimicrobial activity while the Fe (II) complex exhibited the least activity against the bacteria and fungi organisms.